The typical mean particle size is 20200 m. The cellulose molecule is formed through repeated condensation of cellobiose units. Production of Pharmaceutical Grade Microcrystalline Cellulose. /MediaBox [0 0 612 792] Biologicals by FMC. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. CAS 9004-34-6, pH 5 - 7.5. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. << No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . The most. Micro Crystalline Cellulose. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Created Date: 2/10/2020 8:51:41 PM . (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Aqueous suspensions of microcrystalline cellulose have . 130. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Microcrystalline Cellulose Side Effects. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. The figure below illustrates the structural organisation of cellulose within plants. Microcrystalline cellulose is a commonly used excipient in the . PDF (28.38 mb) 2022 Corporate Fact Sheet. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. A family of polysaccharide products that allow distinctive drug delivery solutions. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * 0.25 - 0.37. 4 0 obj MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. /Type/Page Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. 1 0 obj };khd5x=fr : 160182. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Some substance identifiers may have been claimed confidential, or may . The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. All rights reserved. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Manufacturer: FMC BioPolymer. stream EMCOCEL 90 M. 130. Cellulose microcrystalline. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Buy Chemicals. We respect your privacy FMC Privacy Policy. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Trademarks: Avicel PH-102. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC /Resources 2 0 R Origin(s): Plant/Botanical. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Validity Area. These grades have particle sizes ranging from <30 to approximately 200. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Truly distinctive drug delivery solutions. Chemical Formula: (C6H10O5)n 1.4. endobj Millipore. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. In large quantities it provides dietary bulk and may lead to a laxative effect. % XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. : 1. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. ( >> However, it yields non-digestible fibre. Packaging: 34 x 50 kgs fiber drums. ( Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Remove endobj Learn about FMC's differentiated biologically-based crop solutions. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Microcrystalline Cellulose (MCC) Manufacturing Industry. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz The short-term limit for total inhalable dust is 20 mg/m3. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. % SUBSTANCE IDENTIFICATION 1.1. stream These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. By producing Avicel . vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? <> pH 6.0 to 8.0 . 1 0 obj P}MFbN#[>r(y Microcrystalline Cellulose / Avicel PH-102. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. gwf;J(e0o|1p{R~P^);ao!%{0KD7. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. The aqueous solution to barrier membrane coating. 1. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Fiber supplements can lessen the absorption of some . Magazine: Material safety data sheet - FMC Corporation. . Home. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. 51395-75-6 Avicel RC 591. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Alginates also function as actives in some anti-reflux products. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. It is also used in plaque assays for counting. It is available in different grades and particle sizes. Microcrystalline Cellulose. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. It . Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Looking for FMC'searnings news? FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. q9;v80q>jZ Instead, they obtained a stable colloidal suspension. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. <> More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Go to Investor Relations. Cellulose microcrystalline for column chromatography. CAS #: 9004-34-6 . Avicel RC-591 & CL-611 - Description. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. No. Protect them from sunshine or rain. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. If you are already a ChemPoint customer then sign up for access to our online ordering website. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. <> 6 0 obj %PDF-1.4 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. >> These, in turn, are assembled into fibrils in the cell wall. PharmaCentral 2021 . Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Thus, Avicel contributes no or very few calories to the food system. 4. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. CAS 9004-34-6. ). If breathing is difficult or if . . More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. . It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. endobj FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! It is, however, a good source of fibre. Gloves, eye protection and a dust mask should be used. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Microcrystalline Cellulose E460 MSDS 1. % LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . EMCOCEL XLM 90. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. 1 0 obj CAS No. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. BIOACCUMULATIVE POTENTIAL The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. stream Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Manufactured by: China . <> This Microcrystalline Cellulose . Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. We know that our customers need to provide reliable and consistent products to their patients. In 1964 FMC, Corporation . SDS - Safety Data Sheet. stream Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. MATERIAL SAFETY DATA SHEET Version: 1.0 1. Well-recognized product that can do it all. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Microcrystalline Cellulose; Cellulose; Functions. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. cas:9032-51-3 msds CELLULOSE PAB. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. 2 0 obj MSDS Ref. There may be more fiber in your food than you realized. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Medium size standard MCC grade, suited for the majority of directly compressible actives. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. (1962). The 'Substance identity' section is calculated from substance identification information from all ECHA databases. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. endobj As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. common form is used in vitamin supplements or tablets. CAS #: 9004-34-6 1.6. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Are you looking for information about products and services by region? Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. << Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. %PDF-1.5 This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Date Approved: 05/25/2010. Product Name: Microcrystalline Cellulose E460 1.2. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Powder becomes slippery when wet. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. FMC Corporation. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. MCC helps in the formation of spheres because of its . Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . }o]X4]. 9,LL!z At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Revision No. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. [FMC Study Number I92-1464]. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. ( stream Explore how we work and why we apply science and creativity for a better world to everything we do. 1.3. In extrusion-spheronisation, it is the excipient of choice. << Document(s): certificate data msds. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? PDF (2.77 mb) 2021 FMC Sustainability Report. 1.3. Quantity: 1 700 kgs. 3 0 obj ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? MSDS Ref. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. (&E. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. We are artists at heart and creators by nature. . Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. : 160182 Date Approved: 05/25/2010 Revision No. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Delivering efficient and robust formulations. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. : 5. Van Veen, G.K. Bolhuis, Y.S. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). We can send by Fedex, by ship or by plane according to international rules. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. MATERIAL SAFETY DATA SHEET. : 9004-34-6 Date Approved: 01/31/2008 . endstream Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . 6 JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . SCMm_>x^O9l (n. <> Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Microcrystalline Cellulose NF. Are you sure you want to delete your template? >> ( All Rights Reserved. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder.