Fanouriakis A , Sengupta M , ODell JR Background Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Physician Global Assessment to Track Outcomes - JAMA , Petri MA , Garabajiu M antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). [84] expressed the sensitivity in PGA scoring with the standardized response mean (SRM), demonstrating a very large effect size (ES=2.23) [110]. Whenever papers reported duplicate data, the most recent article was selected. Laboratory investigation results influence Physicians Global ssessment (PGA) of disease activity in SLE. Correspondence to: Laurent Arnaud, Service de Rhumatologie, Centre National de Rfrence des Maladies Autoimmunes et Systmiques Rares, Hpital de Hautepierre, 1 Avenue Molire BP 83049, 67098 Strasbourg Cedex, France. . Despite the need for new treatments in CLE . Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . Criterion validity. , Urowitz MB. et al. Parodis I It operates in Albuquerque, and New Mexico. Jesus D et al. There is no cure for lupus, but medical . PGA0.3. 2022 May;9(1):e000700. government site. , Gomez A Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. Glossary: PGA. , Kraag GR The site is secure. 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; The responsiveness of the PGA is the ability to detect worthwhile variations in disease activity over time, measuring worsening or improvements in SLE disease status. Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. PDF Physician s global assessment is often useful in SLE, but not always In 1988, Liang et al. They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). Ward et al. et al. The literature search identified 91 studies. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. et al. Associations between physicians' global assessment of disease activity watch for seizures after the procedure. SELENA SLEDAI4. HHS Vulnerability Disclosure, Help In an epratuzumab trial, the absence of deterioration of the PGA (not >10% worsening) was one of the items to achieve a BILAG-based Composite Lupus Assessment (BICLA) response [105]. The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. Learn more. Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. et al. 2014 - 20184 years. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases , Magder LS , Giannakou I Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. Methods The results are similar, and less than half the time is required for scoring. Construct validity. PGA - Lupus Research It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. The judgment of whether a patient with SLE has active disease is a central question both in routine patient management and in clinical research [4]. 215 (FIVE YEARS 146) H-INDEX. FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). et al. Patient global assessment in measuring disease activity in rheumatoid et al. , Sato JO A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. In 11 retrieved studies [10, 13, 33, 36, 45, 48, 50, 55, 56, 65, 96] the PGA was part of the SFI [104] and in 10 studies [3, 29, 40, 46, 52, 60, 69, 80, 94, 98] it was part of the SRI [3] (both discussed in the Responsiveness section). In the absence of a consensus, Aranow [26] found a better correlation between the SLEDAI and the PGA when the latter was assessed taking into account laboratory test results. The SELENA-SLEDAI assesses systemic lupus erythematosus (SLE) disease activity and categorizes mild/moderate or severe flares based on changes in the SLEDAI score, the Physician's Global Assessment (PGA), medication use (prednisone, Nonsteroidal anti-inflammatory drugs, Plaquenil, major immunosuppressives), other disease activity criteria, and . , Gladman DD The Validity of Patient and Physician Global Disease Activity Changes in the PGA correlated with changes of other disease activity indices (SLEDAI, SLAM, LAI, patient global assessment), laboratory exams (ESR), patient-reported outcomes (Lupus Impact Tracker) [23, 50, 58, 77, 78, 81, 83] and response to treatment [4]. Content validity was reported in 89 studies. Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. et al. Observed and articulated management issues and responses. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. AU - Kasitanon, Nuntana. . CareerBuilder TIP. However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. , Saad-Magalhes C , Emamikia S et al. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. Pincus and colleagues conducted a study of . Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. Tel: 03 88 12 84 74; Fax: 03 88 12 82 90; E-mail: Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research, Patterns of disease activity in systemic lupus erythematosus, Novel evidence-based systemic lupus erythematosus responder index, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus, Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus, Treatment target in newly diagnosed systemic lupus erythematosus, 10 most important contemporary challenges in the management of SLE, Measurement of systemic lupus erythematosus activity in clinical research, Definition, incidence, and clinical description of flare in systemic lupus erythematosus. Barr SG , Klein-Gitelman MS , Carpenter AB In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. , Gladman DD. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36]. In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. Fanouriakis A BILAGAB . European League Against Rheumatism. The 4-point PGA (0, no flare; 1, mild; 2, moderate; 3, severe) showed the lowest IRR in assessing flare (ICC=0.18) compared with the BILAG-2004 (ICC=0.54) and SFI (ICC=0.21) [65]. Thanou A, Chakravarty E, James JA, Merrill JT. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. AU - Morand, Eric. , Borghoff K Systemic Lupus Erythematosus (SLE) | CDC , Block JA The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. Ann Rheum Dis 2011;70:54-9. Conclusion: Content validity. Your recommendations as to what might or should be done in relation to various issues observed. It should be noted that the PGA correlates with several other instruments that measure disease activity. , Engel SM Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. physician global assessment Latest Research Papers | ScienceGate