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Aircraft wastewater surveillance could be used with traveler-based surveillance to provide an early warning system for COVID-19 and other pathogens. 387, 187189 (2022). Baden, L. R. et al. Data from the COVID-19Associated Hospitalization Surveillance Network (COVID-NET) were analyzed to compare COVID-19associated hospitalization rates among adults aged 18 years during B.1.617.2 (Delta; July 1December 18, 2021) and Omicron (December 19, 2021January 31, 2022) variant predominance, overall and by race/ethnicity and vaccination status. N. Engl. Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Gordon, N. & Lin, T. The Kaiser Permanente Northern California adult member health survey. By submitting a comment you agree to abide by our Terms and Community Guidelines. In the present study, the mothers of only 32% of infants in the cohort received at least 2 doses during pregnancy. SARS-CoV-2 delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness. Accessed March 10, 2022. Perm. Viruses | Free Full-Text | SARS-CoV-2 Seroprevalence among Canadian Wkly Rep. 71, 352358 (2022). Rep. 70, 895899 (2021). Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19COVID-NET, 13 states, March 1August 22, 2020. Monthly COVID-19 hospitalization rates were 3.5 to 17.7 times higher in unvaccinated patients than in their vaccinated counterparts, regardless of whether they had received a booster. How likely is COVID-19 hospitalization for vaccinated Americans? - USAFacts Adults who received booster doses were classified as those who completed their primary vaccination series and received an additional or booster dose of vaccine on or after August 13, 2021, at any time after the completion of their primary series, and 14 days before a positive test result for SARS-CoV-2, because COVID-19associated hospitalizations are a lagging indicator, and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255). Late last year, as Omicron was spreading fast in the US, hospitalization rates per 100,000 rose sharply among unvaccinated adults, while rates in those who were fully vaccinated remained. #FridayNight | #FridayNight | By Citizen TV Kenya | Facebook | Good Using previously described methods (3), investigators collected clinical data on a representative sample of adult patients (7.9%) hospitalized during July 1, 2021January 31, 2022, stratified by age and COVID-NET site. For mothers of infants in the cohort, we extracted from the electronic health record data: age at pregnancy onset, self-reported race/ethnicity (Asian, Black, Hispanic, Pacific Islander, Multiracial, Native American, Other, White), the primary KPNC facility at which the woman received most of their health care, insurance payor (dichotomized as Medicare/Medicaid/other subsidized insurance and Other), neighborhood deprivation index [NDI]35 categorized into quartiles with higher values representing greater deprivation), pre-pregnancy body mass index (BMI=kg/m2; underweight <18.5, normal 18.524.9, overweight 25.029.9, obese 30.0), pre-pregnancy diabetes status, pre-pregnancy hypertension, and parity (0, 1, 2, 3, 4). During the Omicron-predominant period, peak hospitalization rates among non-Hispanic Black (Black) adults were nearly four times the rate of non-Hispanic White (White) adults and was the highest rate observed among any racial and ethnic group during the pandemic. Furthermore, it was reassuring that both the cohort and the secondary TND yielded vaccine effectiveness estimates in the same direction. Libby Reeg reports grants from the Michigan Department of Health and Human Services during the conduct of the study. https://www.cdc.gov/mmwr/volumes/70/wr/mm7050e2.htm, Adults who completed their primary COVID-19 vaccination series were defined as those who had received the second dose of a 2-dose primary vaccination series or a single dose of a 1-dose primary vaccine product 14 days before receipt of a positive SARS-CoV-2 test result associated with their hospitalization but received no additional or booster dose. Infect. Ousseny Zerbo. J. https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1, https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb. To obtain COVID-19; IL-6 . Omicron and the vaccines: Your questions answered | AAMC Nursing home residents have been disproportionately affected by COVID-19; older age, comorbidities, and the congregate nature of nursing homes place residents at higher risk for infection and severe COVID-19-associated outcomes . BNT162b2 vaccine effectiveness against omicron in children 5 to 11 years of age. These data should be taken with a grain of salt. 384, 21872201 (2021). Other studies found similarly decreased proportions of severe outcomes among hospitalized patients with COVID-19 during this period (6).. A recent study found that the mean titer of maternally derived antibodies in infants of vaccinated mothers were higher at age 2 months compared with antibody titers at age 6 months23. JAMA Netw Open 2021;4:e2130479. PubMed T.R. All adjustment variables were selected a priori based on prior work36. Most mothers (1032 of 1138) who received only one dose received the vaccine during the third trimester. TN and NMF were responsible for visualisation. Third, because immunocompromise status is not always known, it is not possible to distinguish between booster and additional doses; this could have influenced observed rates. Views equals page views plus PDF downloads. TN, NMF, SGN, DDA, AMP, and ST wrote the original draft of the manuscript. All adults should stay up to date with COVID-19 vaccination to reduce their risk for COVID-19associated hospitalization. Surveillance officers abstracted data on sampled patients from medical charts. PubMed For children whose mothers received one dose before pregnancy and two doses during pregnancy, VE against infection was 89% during the first 2 months of life, 73% during the first 4 months of life, and 48% up to 6 months of life. We observed a similar pattern in vaccine effectiveness by trimester during the Omicron dominant period, however, estimates of vaccine effectiveness by trimester were imprecise and much lower than during the Delta period (Table3). Age-adjusted rates were calculated by dividing the number of hospitalized COVID-19 patients by population estimates for race/ethnicity, and vaccination status in the catchment area. Klein, N. P. et al. Adults who received booster doses were classified as those who completed the primary series and received an additional or booster dose on or after August 13, 2021, at any time after completion of the primary series, and 14 days before a positive test result for SARS-CoV-2, because COVID-19associated hospitalizations are a lagging indicator and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255). JAMA 326, 16291631 (2021). However, protection estimates greater than 90% might be too high if individuals with a previous infection were more likely than those without one to come forward for a test for reasons other than suspicion of COVID-19. Hospitalization of Infants and Children Aged 0-4 Years with Lab Abbreviations: COVID-NET = COVID-19Associated Hospitalization Surveillance Network; ICU=intensive care unit; IMV=invasive mechanical ventilation; LTCF=long-term care facility; NA = not applicable. A previous study conducted before the Omicron-predominant period that showed increased risk for COVID-19associated hospitalization among certain racial and ethnic groups, including Black adults, and suggested the increased hospitalization rates were likely multifactorial and could include increased prevalence of underlying medical conditions, increased community-level exposure to and incidence of COVID-19, and poor access to health care in these groups (7). According to the CDC, hospitalization rates among the unvaccinated were 16 times higher in December overall. Thompson, M. G. et al. Effectiveness of BNT162b2 vaccination during pregnancy in preventing hospitalization for SARS-CoV-2 in infants. Members receive almost all their medical care at KPNC-owned facilities, including clinics, hospitals, pharmacies, and laboratories. If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV Pfizer and BioNTech Submit for U.S. Emergency Use Authorization of Science brief: omicron (B.1.1.529) variant. Cite this article. Implementing strategies that result in the equitable receipt of COVID-19 vaccinations among persons with disproportionately higher hospitalizations rates, including non-Hispanic Black adults, is an urgent public health priority. Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, https://doi.org/10.1038/s41467-023-36547-4. of pages found at these sites. 552a; 44 U.S.C. The outcomes were the infants first positive nasal/throat swab for SARS-CoV-2 by PCR, and the first COVID-19-related hospitalization, occurring during the first 6 months of life and recorded in the electronic health record. National influenza and COVID-19 surveillance report: 27 January 2022 (week 4). Several conditions, including cancer of the blood or bone marrow and dementia, were associated with HRs greater than 3. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Method: This case-control study aims to determine the hospitalization risk associated with the inactivated BBIBP-CorV (Sinopharm) and mRNA BNT162b2 (Pfizer . PubMedGoogle Scholar. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. COVID-19 vaccination during pregnancy: coverage and safety. COVID hospitalizations amid omicron 23 times higher among - ABC News Finally, we conducted additional supplemental analyses to estimate VE among children whose mothers received at least one vaccine dose prior to pregnancy onset and at least one dose during pregnancy. Internet Explorer). The proportion of hospitalized Black adults who received a primary COVID-19 vaccination series with or without a booster or additional dose increased from 4.7% and 14.9%, respectively, during the Delta-predominant period to 14.8% and 25.5%, respectively, during the Omicron-predominant period; Hispanic adults experienced smaller increases. State data show the average age for COVID deaths was about 80 in late 2020, but dropped in spring 2021 to as low as 69 after most older adults received their first COVID vaccines. Shimabukuro, T. T. et al. SGN, HHW, NA, WH, MK, PB, AZ, JLB, MC, NAA, KH, RH, AC, GD, and ST curated the data. and JavaScript. This preceded and had no relation to COVID-19, and GD had no role in and received no funding from the project. Vaccination status (unvaccinated, receipt of a primary series only, or receipt of a primary series plus a booster or additional dose) was determined for individual hospitalized patients and for the catchment population using state immunization information systems data (2). Garg S, Patel K, Pham H, et al. Am. Hospitalizations of Children Aged 5-11 Years with Laboratory Although the study was unable to directly estimate VE against hospitalization due to the small number of hospitalized cases, it found that over the entire study period, the incidence rate of hospitalization during the first 6 months of life was much lower among the infants whose mothers were vaccinated during pregnancy compared with those whose mothers were not vaccinated. Real-world data suggest lower COVID-19 vaccine effectiveness against Omicron variants11,12,13,14. We also conducted analyses based on the trimester during which the vaccine was received during pregnancy (first, second, or third trimester). Iowa does not provide data on vaccination status. Foo, D., Sarna, M., Pereira, G., Moore, H. C. & Regan, A. K. Longitudinal, population-based cohort study of prenatal influenza vaccination and influenza infection in childhood. While Omicron caused a big spike in COVID-19 cases, vaccinated people continued to be less likely to be hospitalized than the unvaccinated. Wkly. Weekly COVID-19-associated hospitalization rates among U.S. infants and children aged 0-4 years have declined since the peak of January 8, 2022; however, peak rates during Omicron predominance were approximately five times those of the peak during Delta predominance. We excluded these infants because we were primarily interested in estimating the effectiveness of mRNA vaccines received during pregnancy; (7) mothers who received adenovirus vector vaccines or any non-mRNA platform vaccines during pregnancy; (8) mothers who did not receive their mRNA vaccinations in accordance with CDC recommendationse.g., the timing between dose 1 and dose 2 was not within the recommended intervals; and (9) infants who did not become KPNC members within two calendar months of their birth. During the Delta period, we found that protection extended through the infants first 6 months of life. Compared with the Delta-predominant period, the proportion of unvaccinated hospitalized Black adults increased during the Omicron-predominant period. https://doi.org/10.1016/j.jpeds.2022.09.059 (2022). J. Obstet. Vaccine effectiveness for 1 dose during the first 6 months of life was 68% (95% CI: 12, 88) (Table2). https://www.medrxiv.org/content/10.1101/2021.08.27.21262356v1 Partially vaccinated adults, and those who received a single dose of a 1-dose product <14 days before the positive SARS-CoV-2 test result were not included in analyses by vaccination status but were included in rates and overall proportions that were not stratified by vaccination status.