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The median interval from vaccination to symptom onset was 2 days (range=040 days); 92% of patients experienced onset of symptoms within 7 days of vaccination. <>/ExtGState<>/Pattern<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 960 540] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> <> of pages found at these sites. Montgomery J, Ryan M, Engler R, Hoffman D, McClenathan B, Collins L, Loran D, Hrncir D, Herring K, Platzer M, Adams N, Sanou A, Cooper LT Jr. JAMA Cardiol. Among teenaged boys the group with the highest risk of myocarditis after COVID-19 vaccination the risk is between 2 and 5 times higher after SARS-CoV-2 infection than after vaccination.10, A study of children ages 12 to 17 in England estimated that COVID-19 vaccination prevented 4,500 hospitalizations, 300 ICU hospital stays, and 36 deaths during the summer of 2021 when infection rates were high.11, Children with myocarditis linked with vaccination are less likely to be hospitalized, admitted to the ICU, or need ventilator support, compared with children who had myocarditis after a COVID-19 diagnosis. According to an analysis presented by a C.D.C. Accessibility endobj COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine These are normal signs that your body is making protective antibodies. Disclaimer. Exposures: Myocarditis Occurring After Immunization With mRNA-Based COVID - JAMA Incidence of multisystem inflammatory syndrome in children among US persons infected with SARS-CoV-2. FLEG: Vaccination helps protect people from getting sick or severely ill with COVID-19 and helps protect those around them. Myocarditis. Myocarditis | American Heart Association COVID-19 is more likely than vaccines to cause myocarditis, and symptoms and outcomes are often worse. Evidence suggests that AstraZeneca and Novavax are probably associated with a small increased risk of myocarditis and pericarditis. Bookshelf CDC is not responsible for the content Heart 2013;99:16814. There might be a 2.5 times higher . Reporting rates of adverse events following COVID-19 vaccination, including those from booster doses, are very stable. Among all participants aged 16 to 24, myocarditis rates were 18.8 and 4.4 per 100,000 person-years for males and females, respectively. DOI: http://dx.doi.org/10.15585/mmwr.mm7027e2external icon. Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Reports of Guillain-Barr Syndrome After COVID-19 Vaccination in the United States. The median age of the 323 patients meeting CDCs case definitions was 19 years (range=1229 years); 291 were male, and 32 were female. doi: 10.1001/jamanetworkopen.2022.18505. All HTML versions of MMWR articles are generated from final proofs through an automated process. 2 0 obj Young Men's Myocarditis Risk 5 Times Higher With Moderna vs Pfizer Vax Moderna Reveals Slightly Higher Rates of Myocarditis in Young - Yahoo! https://www.cdc.gov/vaccines/covid-19/info-by-product/janssen/risk-benefit-analysis.html. At the time of this report, 323 of these 484 cases were determined to meet criteria in CDCs case definitions for myocarditis, pericarditis, or myopericarditis by provider interview or medical record review (Table 1). If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. What are the implications for public health practice? Vaccination with BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna). Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to. Members of the Advisory Committee on Immunization Practices COVID-19 Vaccines Safety Technical Work Group: Robert Hopkins, National Vaccine Advisory Committee; Kathryn Edwards, Vanderbilt University School of Medicine; Lisa Jackson, Kaiser Permanente Washington Health Research Institute; Jennifer Nelson: Kaiser Permanente Washington Health Research Institute; Laura Riley, American College of Obstetricians and Gynecologists; Patricia Whitley-Williams, National Medical Association; Tatiana Beresnev, National Institutes of Health; Karen Farizo, Food and Drug Administration; Hui Lee Wong, Food and Drug Administration; Judith Steinberg, U.S. Department of Health and Human Services; Matthew Clark, Indian Health Service; Mary Rubin, Health Resources & Services Administration; Fran Cunningham, Veterans Administration; Limone Collins, Department of Defense. ACIP also reviewed population-level considerations regarding vaccination. Learn how NIH has improved basic understanding of the SARS-CoV-2 virus and sped up the development of COVID-19 vaccines, treatments, and testing. From an analysis done on just 26 medical chart-confirmed cases of myocarditis in people ages 12 to 39, the CDC scientists estimated a rate of 12.6 cases per million second doses. Unable to load your collection due to an error, Unable to load your delegates due to an error. Myocarditis after RNA-based vaccines for coronavirus. (2022). U.S. reviewing if Moderna shot tied to higher heart inflammation risk "If you're focused on heart inflammation, the safer bet is to take the vaccine," said Mendel Singer at Case Western Reserve University in Ohio, who helped carry out the study. The scientists are monitoring the health of a diverse group of people to learn about the long-term effects of COVID, including heart problems. Comparison of MIS-C Related Myocarditis, Classic Viral Myocarditis, and COVID-19 Vaccine related Myocarditis in Children. Current guidelines from the American Heart Association and American College of Cardiology recommend exercise restriction until the heart recovers.. Shimabukuro TT, Nguyen M, Martin D, DeStefano F. Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS). If you have already gotten the first dose of Pfizer-BioNTech or Moderna vaccine, or if your child has already gotten the first dose of the Pfizer-BioNTech vaccine, its important to get the second dose unless a vaccination provider or your doctor tells you not to get it. Unauthorized use of these marks is strictly prohibited. Because these studies are in their early phases, the results are not ready yet. No potential conflicts of interest were disclosed. There were no cases. Side effects of COVID-19 vaccination are generally mild discomfort at the injection site, fatigue, and muscle aches and go away in a few days. The ACIP recommendation for use of mRNA COVID-19 vaccines under an EUA is interim and will be updated as additional information becomes available. Moderna - 19 case of myocarditis and 19 cases of pericarditis out of 20 million doses given Five people died. Only about 1 out of 100 cases of heart inflammation linked with COVID-19 vaccines is life-threatening.5 An analysis of 627 cases of vaccine-linked myocarditis worldwide showed that 626 fully recovered and one fatality.7. Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military. mRNA Vaccine Technology: A Promising Idea for Fighting HIV, Testing of mRNA HIV vaccines in humans is underway. Myocarditis Following COVID-19 - US News Health The clinical presentation and severity of myocarditis vary among patients. The most common treatment was nonsteroidal anti-inflammatory drugs (589/676; 87%). Severe problems linked with myocarditis include chest pain, arrhythmias, trouble breathing, ankle or leg swelling, and fainting. COVID-19 mRNA vaccination and myocarditis or pericarditis Feelings of having a fast-beating, fluttering, or pounding heart Myocarditis and pericarditis have rarely been reported. Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases. This risk should be considered in the context of the benefits of COVID-19 vaccination. Questions or messages regarding errors in formatting should be addressed to Chary M, Barbuto AF, Izadmehr S, Tarsillo M, Fleischer E, Burns MM. COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Vaccines, Monoclonal Antibodies, and Immunotherapeutics). Pericarditisis inflammation of the outer lining of the heart. The risk of getting myocarditis from a COVID-19 vaccine is less than 1%. Yes. FDA adds warning of rare heart inflammation to Pfizer, Moderna - CNBC [Preprint]. Most of the suspected myocarditis cases in that study developed after the second dose and were among males between 12 and 39 years old. Myocarditis risk higher after Covid infection than Pfizer or Moderna CDC twenty four seven. At that meeting, a chart showed that through early June, there was a higher rate of myocarditis among people who received Moderna than Pfizer-BioNTech about 20 per 1 million doses for. Results: According to the CDC, as of June 23, 2021, more than 177 million people had received at least one dose of a COVID-19 vaccine in the U.S. Among persons with reported myocarditis after mRNA vaccination, the median age was 26 years (range=1294 years), with median symptom onset interval of 3 days after vaccination (range=0179). JAMA Netw Open. Information on how to submit a report to VAERS is available at https://vaers.hhs.gov/index.htmlexternal icon or 1-800-822-7967. PDF Information for Clinical Staff: Myocarditis and mRNA Vaccines Clipboard, Search History, and several other advanced features are temporarily unavailable. Among individuals older than 40 years of age, there were no more than 8 reports of myocarditis for any individual age after receiving either vaccine. Adenoviral Vector-Based Vaccine Platform for COVID-19: Current Status. All information these cookies collect is aggregated and therefore anonymous. Reporting rates of myocarditis > background rates for males (12-49 years, depending upon dose and manufacturer) and females (after dose 2, 12-29 . Active monitoring includes reviewing data and medical records and evaluating the relationship toCOVID-19vaccination. Myocarditis and pericarditis have rarely been reported. The text reads: "Myocarditis is irreversible. Last week, after reviewing data from a clinical . Association Between Myocarditis and Mortality in COVID-19 Patients in a Large Registry. If you have any health problems after vaccination, report them to theVaccine Adverse Event Reporting System. On June 23, 2021, the Advisory Committee on Immunization Practices concluded that the benefits of COVID-19 vaccination to individual persons and at the population level clearly outweighed the risks of myocarditis after vaccination. Its also possible that myocarditis linked with vaccination is less serious because of the younger average age and healthier status of people getting vaccinated. Moderna said the majority of the infections were mild. * Persons who lack the listed symptoms but who meet other criteria may be classified as subclinical myocarditis (probable or confirmed). Using the Dallas criteria (Aretz HT, Billingham ME, Edwards WD, et al. Informed by early reports, CDC prioritized rapid review of myocarditis in persons aged <30 years reported during May 1June 11, 2021; the 484 patient records in this subset were evaluated by physicians at CDC, and several reports were also reviewed with Clinical Immunization Safety Assessment Project investigators, including cardiologists. Main outcomes and measures: Abara WE, Gee J, Marquez P, Woo J, Myers TR, DeSantis A, Baumblatt JAG, Woo EJ, Thompson D, Nair N, Su JR, Shimabukuro TT, Shay DK. stream More information is available, Travel requirements to enter the United States are changing, starting November 8, 2021. scientist on Monday, every million doses of the Pfizer vaccine administered to 16- and 17-year-old boys would be expected to cause 73 cases of the . PDF Updates on myocarditis and pericarditis following Moderna COVID -19 This analysis did not include the potential benefit of preventing post-COVID-19 conditions, such as prolonged symptoms and MIS-C (6,7). The estimated incidence of myocarditis was 2 per 100,000 individuals, with the highest reported rate in males aged 16 to 29. ** The ACIP COVID-19 Vaccines Safety Technical (VaST) Work Group, comprising independent vaccine safety expert consultants, had also reviewed safety data on myocarditis after receipt of mRNA COVID-19 vaccines at its weekly meetings. Thank you for taking the time to confirm your preferences. A histopathologic definition and classification. . Myocarditis related to COVID-19 vaccines seems to be caused by the bodys immune response to vaccination. Parents should speak with their childrens health care providers regarding the benefits and risks of vaccination against COVID-19. Broken down by age and sex, a second dose of the Moderna vaccine was associated with a higher rate of myocarditis or pericarditis compared with a second dose of the Pfizer/BioNTech vaccine among males ages 18 to 24 (adjusted rate ratio 6.6; 95% CI 3.3-13.2) and 25 to 39 (adjusted rate ratio 5.1; 95% CI 2.3-11.5), as well as females ages 18 to . Symptoms typically include chest pain, dyspnea, or palpitations, although other symptoms might be present, especially in younger children (3). The EUA fact sheets should be provided before vaccination; in addition, CDC has developed patient and provider education materials about the possibility of myocarditis and symptoms of concern, to ensure prompt recognition and management of myocarditis. Researchers added together cases after first and second doses to reach a total rate of 77 cases per million in this male age group triggered by vaccination, a sixth that seen after infection. Of the nearly 21 million women, 7.2 million (34%) were younger than age 40, and a slightly increased risk of myocarditis was found among this younger age group after receiving a second dose of the Moderna COVID-19 vaccine: 7 estimated extra cases of myocarditis for every one million women vaccinated. An elevated risk for myocarditis among mRNA COVID-19 vaccinees has been observed, particularly in males aged 1229 years. Between 2001 and 2020, the Institute has funded 139 myocarditis studies at a cost of $43.6 million. doi: 10.1001/jamanetworkopen.2022.53845. "In general, the rate of myocarditis or myopericarditis was about threefold to fourfold higher for mRNA-1273 (Moderna) vaccination than that for BNT162b2 (Pfizer-BioNTech) vaccination," the study said. Trends in acute myocarditis related pediatric hospitalizations in the United States, 20072016. Dr Edwards reported receiving grants from the National Institutes of Health; receiving personal fees from BioNet, IBM, X-4 Pharma, Seqirus, Roche, Pfizer, Merck, Moderna, and Sanofi; and receiving compensation for being the associate editor of Clinical Infectious Diseases. We spoke with Fleg about the risk of myocarditis linked with COVID-19 illness and with vaccines. It affects fewer than 20 people per 1,000,000 COVID-19 vaccinations.3,5,7 Only the mRNA vaccines (Pfizer-BioNTech and Moderna) have been linked with myocarditis. During the COVID-19 pandemic, Fleg turned his attention to the effects of SARS-CoV-2 infection on the heart, including myocarditis. All information these cookies collect is aggregated and therefore anonymous. *** Data collection for race/ethnicity of myocarditis cases is ongoing. Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination - JAMA Moderna COVID-19 shot more likely to cause heart inflammation than Patel, T., Kelleman, West, Z., M., Peter, A., Dove, M., Butto, A., & Oster, M. E. (2021). official website and that any information you provide is encrypted In the past few weeks, anti-vaxxers have rallied behind a nonpeer-reviewed study by a group of Canadian researchers as evidence against COVID-19 vaccines. Regarding health equity considerations, racial and ethnic minority groups have higher rates of COVID-19 and severe disease*****; potential changes in vaccine policy, or anything that would affect vaccination coverage for adolescents or young adults, might disproportionately affect those groups with the highest rates of poor COVID-19 outcomes. Vaccine 2015;33:4398405. Annie, F. H., Alkhaimy, H., Nanjundappa, A., & Elashery, A. An analysis of almost 400 patients with myocarditis linked with COVID-19 illness found that about 15% died within 6 months.9. Getting vaccinated to prevent severe COVID-19 cuts your risk of myocarditis. Fact Check-Most cases of myocarditis after COVID-19 vaccines - Reuters Treatment is often given in a hospital. This term may be used for patients who meet criteria for both myocarditis and pericarditis. Moderna COVID-19 shot likelier to cause heart inflammation - Reuters Myocarditis Risk Varies by COVID-19 Vaccine Type, Dosing Interval While the researchers did observe a higher risk among people that got the Moderna shot, it was still a relatively small risk. The rates of myocarditis were highest after the second vaccination dose in adolescent males aged 12 to 15 years (70.7 per million doses of the BNT162b2 vaccine), in adolescent males aged 16 to 17 years (105.9 per million doses of the BNT162b2 vaccine), and in young men aged 18 to 24 years (52.4 and 56.3 per million doses of the BNT162b2 vaccine and the mRNA-1273 vaccine, respectively). 2022 Jun 11;399(10342):2191-2199. doi: 10.1016/S0140-6736(22)00791-7. Myocarditis, Pericarditis Rare After COVID-19 Vaccination: EMR Data Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. The crude reporting rates for cases of myocarditis within 7 days after COVID-19 vaccination exceeded the expected rates of myocarditis across multiple age and sex strata. ; MIS-C Incidence Authorship Group. CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. If you have concerns about COVID-19 vaccination, talk with your healthcare provider or your childs doctor, nurse, or clinic. The researchers found only 1 case per 71,400 vaccinated with Pfizer-BioNTech and 1 case per 23,800 vaccinated with Moderna. (2022). Follow-up is ongoing to identify and understand longer-term outcomes after myocarditis occurring after COVID-19 vaccination. Those who have been diagnosed with myocarditis should consult with their cardiologist (heart doctor) about return to exercise or sports. On July 6, 2021, this report was posted online as an MMWR Early Release. . Moderna says Covid vaccine has fewer breakthrough cases than Pfizer's Based on ACIPs conclusion regarding the benefit-risk assessment on June 23, 2021, COVID-19 vaccination continues to be recommended for all persons aged 12 years under the FDAs EUA. NHLBI Information & Resources on COVID-19. ACIP emphasized the importance of informing vaccination providers and the public about the benefits and the risks, including the risk for myocarditis after COVID-19 vaccination, particularly for males aged 1229 years. July 5, 2022, U.S. Department of Health and Human Services, Benefits of COVID-19 vaccines outweigh a very small risk of heart complications, You can learn more about myocarditis symptoms, diagnosis, and treatment from the NHLBI, Countermeasures Injury Compensation Program, Researching COVID to Enhance Recovery (RECOVER), CONNECTS-Collaborative Cohort of Cohorts for COVID-19 Research (CONNECTS-C4R), https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-total-admin-rate-total, https://doi.org/10.1161/CIR.0000000000001001, https://doi.org/10.1038/s41591-021-01630-0, https://doi.org/10.1016/j.hrtlng.2020.08.013, https://doi.org/10.1007/s12471-022-01677-9, https://doi.org/10.1016/j.vaccine.2020.12.046, https://doi.org/10.1016/j.ijcard.2022.01.037, https://doi.org/10.1007/s00392-022-02007-0, https://doi.org/10.1016/j.mayocpiqo.2021.12.006, https://doi.org/10.1177/01410768211052589, https://doi.org/10.1101/2021.10.05.21264581. View Large Download. Saving Lives, Protecting People, https://www.cdc.gov/vaccines/covid-19/clinical-considerations/myocarditis.html, https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html, https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-vaccines, https://www.cdc.gov/vaccines/hcp/acip-recs/vacc-specific/covid-19.html, https://www.cdc.gov/vaccines/acip/work-groups-vast/index.html, https://www.ahajournals.org/doi/10.1161/CIR.0000000000000239?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#d3e785, https://www.cdc.gov/vaccinesafety/ensuringsafety/monitoring/cisa/index.html, https://www.cdc.gov/vaccines/covid-19/info-by-product/janssen/risk-benefit-analysis.html, https://covid.cdc.gov/covid-data-tracker/#demographicsovertime, https://gis.cdc.gov/grasp/COVIDNet/COVID19_3.html, https://gis.cdc.gov/grasp/COVIDNet/COVID19_5.html, https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/fully-vaccinated-people.html, https://covid.cdc.gov/covid-data-tracker/#variant-proportions, https://covid.cdc.gov/covid-data-tracker/#demographics, https://www.fda.gov/media/144413/download, https://www.fda.gov/media/144637/download, https://www.cdc.gov/vaccines/covid-19/info-by-product/pfizer/index.html, https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/index.html, https://doi.org/10.1136/heartjnl-2013-304449, https://doi.org/10.1016/j.amjcard.2021.03.019, https://doi.org/10.1016/j.vaccine.2015.07.035, https://doi.org/10.1001/jamanetworkopen.2021.16420, https://www.sciencedirect.com/science/article/pii/S0735109718388430?via%3Dihub, https://academic.oup.com/eurheartj/article/36/42/2921/2293375, Centers for Disease Control and Prevention, U.S. Department of Health & Human Services, Presence of 1 new or worsening of the following clinical symptoms:*, dyspnea, shortness of breath, or pain with breathing. 2023 Feb 1;6(2):e2253845. Data were used for the most recent week not subject to reporting delays prior to the ACIP meeting. Severe myocarditis can cause long-lasting heart damage or even death. Currently, about 1,000 cases of myocarditis and pericarditis have been reported after vaccination against COVID-19 with one of the mRNA vaccines, Pfizer/BioNTech or Moderna. The risk after both doses of the Moderna vaccine in people age 18 to 39 was as much as 37 times as high as in the general population, and the rate after two doses of the Pfizer-BioNTech vaccine. endorsement of these organizations or their programs by CDC or the U.S. COVID-Vaccine Myocarditis: Rare, Mild, and Usually a Guy Thing - Medscape Data from a government agency's safety monitoring system in that month suggested a rate of 12.6 cases of heart inflammation per million in 12-to 39-year-olds. J Med Toxicol. Most of the cases have been reported after receiving a Pfizer-BioNTech or Moderna . The benefit-risk analysis can be updated as needed to reflect changes in the COVID-19 pandemic and additional information on the risk for and outcomes of myocarditis after COVID-19 vaccination. Cordero, A., Cazorla, D., Escribano, D., Quintanilla, M. A., Lpez-Ayala, J. M., Berbel, P. P., & Bertomeu-Gonzlez, V. (2022). Seek medical care if you or your child have any of the specific or general symptoms of myocarditis or pericarditis especially if its within a week after COVID-19 vaccination. But as report after report showed such. In young people aged 12-17 years (boys and girls combined), the rate of myocarditis or myopericarditis in Denmark was 1 per 100 000 with BNT162b2 compared with 18.5 per 100 000 in Hong Kong,3 and roughly 7 per 100 000 in Israel (ages 16-19 years).2 In 12-39 year old males after the second dose of BNT162b2, the incidence of myocarditis or . B, For the mRNA-1273 vaccine, there were 116 reported cases of myocarditis with known date for symptom onset and dose after 78158611 first vaccination doses and 311 reported cases after 66163001 second vaccination doses. Centers for Disease Control and Prevention. Heart inflammation link to Pfizer and Moderna jabs - BBC News <> Acta Paediatr 2021;110:220811. A., Christakis, D. A., Cowell, L. G., Draper, C., Ghildayal, N., Harris, A. M., Kappelman, M. D., Ko, J. Y., Mayer, K. H., Nagavedu, K., Oster, M. E., Paranjape, A., Puro, J., Ritchey, M. D., Gundlapalli, A. V. (2022). Myocarditis usually goes away on its own with supportive care, including IV fluids, steroid therapy, and medicines to treat disorders of heart rhythm or pumping function. Dr Schlaudecker reported receiving grants from Pfizer and receiving personal fees from Sanofi Pasteur. When reported, the cases have especially been in adolescents and young adult males within several days after mRNA COVID-19 vaccination (Pfizer-BioNTech or Moderna). The walls of the heart become inflamed, which weakens the hearts pumping action and can cause irregular heart rhythms, heart failure, and other complications. 1 0 obj Cases of myocarditis and pericarditis, although rare, have occurred more often in younger men (adolescents or young adults) and after the second dose, typically within a few days after . (2022). After reports of myocarditis, the work group met twice to review clinical trial and postauthorization safety data for myocarditis after receipt of mRNA COVID-19 vaccines. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Chavda VP, Bezbaruah R, Valu D, Patel B, Kumar A, Prasad S, Kakoti BB, Kaushik A, Jesawadawala M. Vaccines (Basel). You can learn more about myocarditis symptoms, diagnosis, and treatment from the NHLBI. The 120-day period was selected because 1) no alternative vaccine options currently exist for persons aged <18 years or are expected to be available during this period, and 2) inputs regarding community transmission have high uncertainty beyond this period, particularly in the context of circulating variants.. Myocarditis is a rare complication of COVID-19 vaccination. In December 2020, the Food and Drug Administration (FDA) issued Emergency Use Authorizations (EUAs) for the Pfizer-BioNTech COVID-19 (BNT162b2) vaccine and the Moderna COVID-19 (mRNA-1273) vaccine, and the Advisory Committee on Immunization Practices (ACIP) issued interim recommendations for their use in persons aged 16 years and 18 years, respectively. In May 2021, FDA expanded the EUA for the Pfizer-BioNTech COVID-19 vaccine to include adolescents aged 1215 years; ACIP recommends that all persons aged 12 years receive a COVID-19 vaccine.